A new study on bioactivity of Blueberry by Food Chemistry

The latest, The article "Diversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicity " was published in the British journal Food Chemistry (IF 7.514) , by Protiva Rani Das team at Florida A&M University, may provide insights into the development of new blueberry germplasm with superior fruit quality and nutritional value. 

【 Study on Anticancer Activity of Blueberry extract 】Blueberry extract showed potential to inhibit all three cancer cell groups, and its anticancer activity was dependent on dose and culture time. Statistical analysis showed that the highest anticancer potential was associated with "Vernon" and "Alapaha" varieties. In this paper, the antitumor activity of different varieties and developmental stages of blueberry against human lung cancer A549, liver cancer HepG2 and colon cancer Caco-2 cell lines was determined at four different extract concentrations of 250, 500, 750 and 1000 ng/mL and three culture times of 24, 48 and 72 h.The highest (" Vernon ") and lowest (" Star ") blueberry varieties were selected according to their metabolite content and nutritional value. Further studies showed that "Vernon" had stronger anticancer activity against cancer cells, and the developmental stage -I had higher potential to inhibit the growth of cancer cells than stage-II and stage-III. The higher potency of "Vernon" in inhibiting cancer cell populations may be due to its higher bioactive metabolite content. 

【Study on screening of biomarkers and their correlation with anticancer activity 】

A total of 17 blueberry biomarkers (VIP ≥ 1.0) were screened by partial least squares discriminant analysis (PLS-DA), and the identified biomarkers and anticancer activity were further analyzed by heat map. It was found that the relative content and anticancer potential of metabolites of blueberry were significantly different among different varieties. The higher anticancer activity of the "Vernon" variety compared with "Star" may be due to the higher content of the biomarkers identified. The authors further analyzed the correlation between the anticancer activity of 17 biomarkers, and screened out 5 metabolites with high anticancer potential, and found that the relative content of each biomarker contained by the "Vernon" variety was significantly higher at each developmental stage.The differences among blueberry extracts were mainly due to variety differences. The biomarkers identified in this study and their demonstrated anticancer activity are expected to be of great value in the fields of food, pharmaceutical, nutrition and health products, and it is expected to develop new germplasm with anticancer potential